PROSITE entry PS51150

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51150
Entry name [info]	AGOUTI_2
Accession [info]	PS51150
Entry type [info]	MATRIX
Date [info]	01-OCT-2005 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC60024
Associated ProRule [info]	PRU00494

Name and characterization of the entry

Description [info]

Agouti domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=40;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=36;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.7000277; R2=0.0052378; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2728.9633789; R2=3.2879581; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1108; H_SCORE=6372; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=726; H_SCORE=5116; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-11; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='V';  M=  0,-30,-10,-30,-30,  0,-30,-30, 30,-20, 10, 10,-30,-30,-30,-20,-10,  0, 50,-30,-10,-30;
/M: SY='A';  M= 28,-10,-16,-17, -7,-20, -6,-14,-16,  3,-13,-10, -7,-13, -4,  8,  4, -3, -6,-20,-17, -7;
/M: SY='T';  M= -4, -5,-14,-13,-12, -5,-21,-16, -2,-15,  7, -2, -2,-17,-12,-12,  3, 25,  0,-28, -8,-12;
/M: SY='R';  M=-17,-16,-27,-16, -6,-11,-23, -6,-14, 11,  2, -1, -9,-23,  1, 42,-16,-10,-11,-20, -7, -6;
/M: SY='D';  M=-15, 35,-28, 43, 28,-32,-11,  2,-32,  3,-27,-25, 23, -9,  6, -5,  2, -8,-30,-37,-20, 17;
/M: SY='S';  M= 10,  0,-10,  0,  0,-20,  0,-10,-20,-10,-30,-20, 10,-10,  0,-10, 40, 20,-10,-40,-20,  0;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='K';  M=-10, -9,-27, -9,  1,-17,-23,-13,-14, 25, -5, -1, -9,-16,  1, 14,-16,-10,-11,-20, -7,  1;
/M: SY='P';  M= -4,-14,-32, -8, -6,-28, 11,-18,-26,-13,-30,-20, -9, 40,-12,-18,  1, -9,-27,-28,-28,-12;
/M: SY='P';  M=-13,-14,-37, -7,  0,-27,-20, 18,-23,-10,-27,-14,-11, 55, -4,-14,-10,-13,-30,-30,-14, -7;
/M: SY='A';  M= 31, -7,-16,-14, -1,-26, -6,-11,-13, -4,-13, -7, -7,-10, 12,-11,  7, -3, -9,-20,-17,  6;
/M: SY='P';  M=-10,-24,-35,-22,-12,-16,-27,-23,  7,-19, -5, -3,-21, 41,-14,-23,-15,-10, -6,-26,-17,-17;
/M: SY='A';  M= 31,-13,-19,-17, -7,-23, -6,-20,-13,-10,-16,-13,-13, 22,-10,-20,  4, -3, -9,-23,-23,-10;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='D';  M=-19, 49,-29, 64, 18,-38, -9,  1,-38,  0,-30,-29, 25,-11,  0, -9,  1, -9,-30,-40,-20,  9;
/M: SY='P';  M=-10,-20,-40,-10,  0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='A';  M= 50,-10,-10,-20,-10,-20,  0,-20,-10,-10,-10,-10,-10,-10,-10,-20, 10,  0,  0,-20,-20,-10;
/M: SY='S';  M=  2, -5,-12,-10, -8,  0,-11,-15,-13,-13,-17,-13,  2,-13,-10,-12, 24, 24, -5,-28, -8, -8;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='Q';  M=-13, -6,-30, -6,  7,-18,-23, 13,-14,  4,-14,  0, -6,-16, 38,  4, -6,-10,-24, -4, 18, 21;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='R';  M=-20,-10,-30,-10,  0,-20,-20,  0,-30, 30,-20,-10,  0,-20, 10, 70,-10,-10,-20,-20,-10,  0;
/M: SY='F';  M=-20,-30,-20,-40,-30, 80,-30,-20,  0,-30, 10,  0,-20,-30,-40,-20,-20,-10,  0, 10, 30,-30;
/M: SY='F';  M=-20,-30,-20,-40,-30, 80,-30,-20,  0,-30, 10,  0,-20,-30,-40,-20,-20,-10,  0, 10, 30,-30;
/M: SY='R';  M=-14,  6,-27, -1, -3,-22,  1,  0,-28, 13,-25,-15, 19,-20,  2, 33, -2, -8,-25,-26,-16, -3;
/M: SY='S';  M= 23, -3,-10, -6, -3,-20,  0,-13,-17,-10,-24,-17,  4,-10, -3,-13, 31, 14, -7,-34,-20, -3;
/M: SY='A';  M= 26,-16,-13,-25,-16, 12, -9,-19, -7,-16, -5, -7,-12,-16,-19,-19,  2, -2, -1,-12, -4,-16;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='T';  M= -3, -6,-16, -9, -9, -1,-16, -4,-11,-10,-14,-11, -3,-16, -6,-10, 15, 20, -7,-15, 15, -9;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='R';  M=-20,-10,-30,-10,  0,-20,-20,  0,-30, 30,-20,-10,  0,-20, 10, 70,-10,-10,-20,-20,-10,  0;
/M: SY='V';  M= -3,-21,-16,-21,-17, -9,-27,-24, 11,  2, -3,  4,-21,-24,-17, -4,-10, -3, 28,-27,-10,-17;
/M: SY='L';  M=-10,-30,-23,-33,-23,  7,-33,-23, 29,-30, 41, 20,-27,-27,-20,-23,-27,-10, 16,-20,  0,-23;
/M: SY='N';  M=  2, 16,-14,  7, -1,-19, -1, -3,-19, -6,-29,-19, 29,-14, -1, -6, 27, 14,-17,-39,-19, -1;
/M: SY='P';  M= -8,-14,-28,-11, -5,-20,-21,-19,-15, -9,-17,-13,-13, 42, -9,-11, -2,  9,-17,-29,-20,-10;
/M: SY='T';  M= -3,  9,-14, -2, -6,-14,-14,-11,-15, -5,-17,-13, 15,-13, -5, -2, 17, 31, -9,-32,-13, -6;
/I:         I=-14; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.

Total number of hits	48 in 48 different sequences
Number of true positive hits	48 in 48 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	10
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	82.76 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	Agouti
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

48 sequences

AGRP_BOVIN  (P56413), AGRP_HUMAN  (O00253), AGRP_MOUSE  (P56473),

AGRP_PIG(Q9TU18), ASIP_BOVIN  (Q29414), ASIP_CALGE  (A1YL78), 
ASIP_CALGO  (A1YL80), ASIP_CALJA  (A1YL77), ASIP_CANLF  (Q5UK76), 
ASIP_CEBPY  (A1YL79), ASIP_CERMI  (Q1XGU9), ASIP_CHLAE  (Q1XGV1), 
ASIP_COLPO  (Q1XGU5), ASIP_ERYPA  (Q1XGV0), ASIP_FELCA  (Q865F0), 
ASIP_GORGO  (Q1XGV5), ASIP_HORSE  (Q95MP2), ASIP_HUMAN  (P42127), 
ASIP_LEOCY  (A1YL81), ASIP_LEORO  (A1YL82), ASIP_MACAR  (A8CEM9), 
ASIP_MACAS  (A8CEN3), ASIP_MACCY  (A8CEM1), ASIP_MACFA  (Q1XGV3), 
ASIP_MACFU  (A8CEM0), ASIP_MACHE  (A8CEM5), ASIP_MACMR  (A8CEM4), 
ASIP_MACMU  (A1YL67), ASIP_MACNE  (A1YL69), ASIP_MACNG  (A1YL68), 
ASIP_MACNR  (A8CEM7), ASIP_MACRA  (Q1XGV2), ASIP_MACSI  (A8CEN1), 
ASIP_MACSL  (A8CEM8), ASIP_MACSY  (A1YL66), ASIP_MOUSE  (Q03288), 
ASIP_PANPA  (Q1XGV6), ASIP_PANTR  (Q1XGV7), ASIP_PAPAN  (A1YL70), 
ASIP_PIG(Q6ZYM3), ASIP_PONPY  (Q1XGV4), ASIP_RAT(Q99JA2), 
ASIP_SEMEN  (Q1XGU8), ASIP_TRAAU  (A1YL72), ASIP_TRACR  (Q1XGU6), 
ASIP_TRAFR  (A1YL74), ASIP_TRAOB  (Q1XGU7), ASIP_VULVU  (P79407)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

10 sequences

TXD01_LYCSI (B6DD19), TXD02_LYCSI (B6DD20), TXD03_LYCSI (B6DD21),

TXD04_LYCSI (B6DD22), TXD05_LYCSI (B6DD23), TXD06_LYCSI (B6DD24), 
TXD07_LYCSI (B6DD25), TXD08_LYCSI (B6DD26), TXD09_LYCSI (B6DD27), 
TXD10_LYCSI (B6DD28)

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PDB
[Detailed view]

6 PDB

1HYK; 1MR0; 1Y7J; 1Y7K; 2KZA; 2L1J