PROSITE entry PS51133

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51133
Entry name [info]	ZF_TFIIS_2
Accession [info]	PS51133
Entry type [info]	MATRIX
Date [info]	01-JUN-2005 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00383
Associated ProRule [info]	PRU00472

Name and characterization of the entry

Description [info]

Zinc finger TFIIS-type profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=41;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=37;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.4266217; R2=0.0051143; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=4801.4287109; R2=1.2132797; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1384; H_SCORE=6481; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=992; H_SCORE=6005; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-23; D=-20; I=-20; B1=-200; E1=-200; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-105; BD=-105;
/M: SY='T';  M= -17, -49,  11,   4, -34,   0, -14,  14,  -6, -25, -36, -22, -30, -19,   5,  33,  36,   3, -54,   6;
/M: SY='D';  M=  -2, -52,  51,  20, -31, -11, -33, -44,  13, -21,  -8,  31, -45,  25,  -2,   0,  -3, -41, -12,  -6;
/M: SY='W';  M=   4, -52, -42,  22,  17, -52,  33,  28,  13,  -6, -30, -28, -48, -35,  -1, -31,  -3,  10,  53,   6;
/M: SY='K';  M= -26, -54, -32,  29, -52, -41, -38,  -9,  46, -35, -39,  11,  35,  26,   8, -15,  17,  -3, -56, -45;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/I:         I=-6; MD=-32;
/M: SY='P';  M= -33, -63, -34,   3, -43,   6, -43, -51,   2, -48, -46, -42,  95,  -1,   2, -16, -23, -34, -54, -11; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='K';  M=   3, -52,   4,  12, -35, -22, -34, -47,  61, -42, -42,  31, -44,  11,  25,  -6, -30, -20, -54, -27;
/I:         I=-5; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='G';  M= -21, -54,   1, -32, -57,  65,  44, -62,  31, -58, -47,   6, -27,   2, -11,   3, -22, -57, -56, -45;
/M: SY='H';  M= -30, -32, -28, -16,  -4,   4,  87, -55,  16, -51, -41,  54, -47,  16, -30,  31, -28, -54, -61, -24;
/M: SY='N';  M= -29, -54,  29,  20, -53, -13,  34, -41,  27, -41,  -7,  40,   7, -12,  36,  -6,  -9, -44, -60, -30;
/M: SY='E';  M= -38, -54,  10,  58, -28,   1, -20, -54,  37, -52, -22,  38, -41,  -7,  16, -20,  -4, -33, -58, -45;
/M: SY='A';  M=  57,  40, -47, -44, -43, -18, -47, -16, -43, -12,  39, -19, -47, -41, -47, -20,  30,  16, -57, -28;
/M: SY='Y';  M=  -6, -49, -48, -34,  16, -51,  24,   1, -41, -11,   1, -42, -52, -11, -12,   5,  19,  41,  23,  53;
/I:         I=-6; MD=-29;
/M: SY='F';  M= -43, -56, -56, -42,  79, -55, -35, -34, -48, -29, -33, -52,  24, -50, -34, -21, -28, -30,  65,  78; D=-6;
/I:         I=-6; MI=-29; MD=-29; IM=-29; DM=-29;
/M: SY='F';  M= -28, -51, -53, -39,  62, -54,  22,  -7, -21,   1,  37, -22, -55, -35, -11, -24,  10,  -1,  62,  36; D=-6;
/I:         I=-6; DM=-29;
/M: SY='Q';  M= -36, -54, -34,  18, -50, -47,  -9,  -3, -26, -11,  38, -13, -44,  89, -29,  -4,  30, -32, -54, -38;
/M: SY='M';  M=   5, -49, -31, -41, -23, -50, -42,  19,   4,  37,  48, -43, -12,   4,   2,  11, -21,  -2, -52, -36;
/I:         I=-6; MD=-32;
/M: SY='Q';  M= -26, -62, -34, -15, -65, -46,  23, -53, -19, -48, -10, -29,  -1, 113,  -2, -28, -40, -55, -52, -38; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='T';  M= -27, -45, -39,   0, -41, -16, -44,  24, -37,  -1,   9, -32, -42,  16, -43,  -7,  78, -19, -59, -41;
/M: SY='R';  M= -16, -59, -41, -29, -54, -16, -32, -59,  25, -43, -42, -33, -51, -20,  98, -37, -42, -52, -53, -41;
/I:         I=-5; MD=-27;
/M: SY='S';  M=  19, -19, -22, -14, -52, -16, -39, -17,  -9, -50, -44, -29, -45, -28,  27,  73, -23, -26, -59, -45; D=-5;
/I:         I=-5; MI=-27; MD=-27; IM=-27; DM=-27;
/M: SY='A';  M=  71,  -2, -43, -16, -54,  18, -46, -33, -18, -39, -41, -37, -45, -36, -32,  18, -23, -28, -55, -49; D=-5;
/I:         I=-5; DM=-27;
/M: SY='D';  M= -45, -59, 101,  25, -59, -44, -31, -62, -32, -60, -58, -17, -44, -30, -41, -20, -23, -59, -71,   0; D=-5;
/I:         I=-5; DM=-27;
/M: SY='E';  M= -37, -56,  -2,  93, -58, -51, -32, -55, -10, -52, -48,   9, -35, -15, -30, -32,  12, -27, -60, -50;
/M: SY='P';  M=   7, -57, -39,   1, -59,  39, -44, -53, -39, -57, -18, -11,  87, -38, -48,  13, -20, -52, -56, -55;
/M: SY='M';  M= -19, -50, -44,   9, -40, -47, -35, -18, -37,   0,  98, -40,  37,  31, -39,  13,  -1, -31, -54, -37;
/M: SY='T';  M= -11, -42, -39, -39, -43, -45, -45,  -4, -35, -11, -34, -29, -41, -38,   0,  20,  87, -12, -62, -42;
/M: SY='V';  M= -37, -48, -53, -47, -31, -59, -50,  35, -15,  34, -19, -46, -52, -43,  22, -30,  31,  43, -56, -37;
/M: SY='F';  M= -38, -51, -59, -40,  96, -59, -41,  11, -28, -16,  -1, -51, -60, -53,   5, -49, -43, -17, -23,  39;
/M: SY='Y';  M= -15,  14, -52, -52,  51, -55,  22, -21, -46, -24, -28, -49, -60, -44, -44, -43, -41,  11, -17, 101;
/M: SY='V';  M= -14, -11, -33,  -2, -14, -52, -44,   4,  30, -10, -15, -24, -47, -22,  12, -16,  36,  40, -55,  -9;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/I:         I=-5; MD=-27;
/M: SY='C';  M=  -5,  56, -26, -19, -43, -49, -28, -13,  14,   2,   3,  -8,   1, -19,  -9,  -8,  43,   8, -60, -23; D=-5;
/I:         I=-5; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='N';  M= -14, -52,  34,  24, -54, -20,  33, -55,  34, -52, -24,  47, -44,  -3,   8,  22, -18, -42, -61, -24;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/I:         I=-6; MD=-32;
/M: SY='G';  M= -14, -54, -30, -16, -39,  65, -25, -58,  31, -45, -27,  11, -46,  21, -13,  -1, -33, -54, -51,  -9; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='H';  M= -44, -55, -22,  -2,  25, -47,  99, -51,  35, -44, -36,  26, -48,  -7, -26, -19, -39, -52, -46,  44;
/M: SY='R';  M= -24, -55, -29, -15, -34, -49,  22, -14,  28, -20, -36,   8, -48,  32,  62, -24,  10, -14,  40, -14;
/M: SY='W';  M= -50, -65, -50,  -2,  56, -54, -57, -41, -46, -37, -12, -60, -55, -31, -36, -52, -22, -32, 148,  17;
/M: SY='R';  M= -24, -52, -36,  -8, -51, -48, -36, -15,  47, -47, -40,  -9, -45, -14,  64,   6,  38, -22, -56, -42;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.

Total number of hits	66 in 66 different sequences
Number of true positive hits	66 in 66 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Archaea, Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	window20
Author [info]	N_Hulo
Feature key [info]	ZN_FING
Feature description [info]	TFIIS-type
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

66 sequences

081R_FRG3G  (Q6GZP4), RDO2_ARATH  (Q9ZVH8), RP30_MONPV  (A0A7H0DN39),

RP30_VACCA  (O57187), RP30_VACCC  (P21082), RP30_VACCW  (P21603), 
RP30_VAR67  (P33796), RPA12_BOVIN (Q1RMP0), RPA12_HUMAN (Q9P1U0), 
RPA12_MACMU (Q5TM50), RPA12_MOUSE (Q791N7), RPA12_PANTR (Q1XHV8), 
RPA12_RAT   (Q6MFY5), RPA12_SCHPO (O94703), RPA12_YEAST (P32529), 
RPB9A_ARATH (Q6NLH0), RPB9B_ARATH (Q8L5V0), RPB9_BOVIN  (Q32P73), 
RPB9_CAEEL  (Q965S0), RPB9_CANGA  (Q6FS48), RPB9_DROME  (P36958), 
RPB9_ENCCU  (Q8SQU1), RPB9_EREGS  (Q755B3), RPB9_HUMAN  (P36954), 
RPB9_MOUSE  (P60898), RPB9_PIG(P60899), RPB9_SCHPO  (O74635), 
RPB9_YEAST  (P27999), RPC10_BOVIN (Q2M2S7), RPC10_HUMAN (Q9Y2Y1), 
RPC10_MOUSE (Q9CQZ7), RPC10_SCHPO (O13896), RPC10_YEAST (Q04307), 
RPO5_FOWPN  (Q9J5C0), TCEA1_BOVIN (Q29RL9), TCEA1_DICDI (Q54YG9), 
TCEA1_HUMAN (P23193), TCEA1_MOUSE (P10711), TCEA1_RAT   (Q4KLL0), 
TCEA2_BOVIN (Q148K0), TCEA2_HUMAN (Q15560), TCEA2_MOUSE (Q9QVN7), 
TCEA2_RAT   (Q63799), TCEA3_BOVIN (Q2KI09), TCEA3_HUMAN (O75764), 
TCEA3_MOUSE (P23881), TFIIS_ASFB7 (P27948), TFIIS_ASFK5 (P0C8F5), 
TFIIS_ASFM2 (P0C8F6), TFIIS_ASFP4 (P0C8F7), TFIIS_ASFWA (P0C8F8), 
TFS1_SACS2  (Q980K2), TFS2_CAEEL  (P52652), TFS2_DROME  (P20232), 
TFS2_MIMIV  (Q5UQS8), TFS2_SCHPO  (P49373), TFS2_YEAST  (P07273), 
TFS_ARCFU   (O29033), TFS_METJA   (Q58548), TFS_METTH   (O27369), 
TFS_METTL   (Q9P9I8), TFS_SULAC   (Q07271), TFS_THECE   (Q56254), 
TFS_THEKO   (Q5JF34), VF349_IIV3  (Q197A5), VF349_IIV6  (Q91FH5)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

393 PDB

1I3Q; 1I50; 1I6H; 1K83; 1NIK; 1NT9; 1PQV; 1QYP; 1R5U; 1R9S; 1R9T; 1SFO;
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