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PROSITE entry PS50240


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS50240
Entry name [info] TRYPSIN_DOM
Accession [info] PS50240
Entry type [info] MATRIX
Date [info] 01-DEC-2001 CREATED;
01-OCT-2013 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00124
Associated ProRule [info] PRU00274

Name and characterization of the entry

Description [info] Serine proteases, trypsin domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=234;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=229;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.0169; R2=0.00836256; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=1134; N_SCORE=9.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=776; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-9; D=-20; I=-20; B1=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.


Total number of hits 824 in 802 different sequences
Number of true positive hits 824 in 802 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 18
Number of 'partial' sequences 81
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 97.86 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 3
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann, N_Hulo
Feature key [info] DOMAIN
Feature description [info] Peptidase S1
Version [info] 3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
802 sequences

ACH1_LONAC  (P23604), ACH2_LONAC  (P23605), ACRO_HUMAN  (P10323), 
» more

UniProtKB/Swiss-Prot
False negative sequences
18 sequences

HTR1B_DANRE (A9JRB3), HTRA1_BOVIN (F1N152), HTRA1_XENLA (A6YFB5), 
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UniProtKB/Swiss-Prot
'Partial' sequences
81 sequences

ACRO_CAPHI  (P10626), CBP_OLIMR   (P0C8M2), CFAB_PIG(Q03710), 
» more

PDB
[Detailed view]
2328 PDB

1A0H; 1A0J; 1A0L; 1A2C; 1A3B; 1A3E; 1A46; 1A4W; 1A5G; 1A5H; 1A5I; 1A61;
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