PROSITE entry PS50002

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS50002
Entry name [info]	SH3
Accession [info]	PS50002
Entry type [info]	MATRIX
Date [info]	01-NOV-1995 CREATED; 22-NOV-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50002
Associated ProRule [info]	PRU00192

Name and characterization of the entry

Description [info]

Src homology 3 (SH3) domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=61;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=61;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3910916; R2=0.0092440; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1040; N_SCORE=12.0; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=445; N_SCORE=6.5; MODE=1; TEXT='R?';
/DEFAULT: M0=-51; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='P';  M=  -4, -92, -21,  13,-121,   7, -13, -35,  16,  -6,   4,  15,  41,  21, -30,  25, -15, -19, -69, -33;
/M: SY='P';  M= -12, -60,   1,  17,  -5,  12, -17, -22,  22, -50, -29,   9,  28,  11,   6,   4, -12,   0, -87,  -9;
/M: SY='P';  M=   4,   0, -41,  12, -46,   9, -17,  16,  -1,  -8,  -6, -44,  44, -11,  -9,   8, -21, -12,   2,   1;
/M: SY='P';  M= -50, -30, -20,  13,   5,  -9,  -9,  -4,  12, -23,  -4,   6,  34,   0,  32,  -3,  -6,   7,-221,  -5;
/M: SY='Y';  M= -45,  20, -56,   3,  11,-221,   6,  -5,  17, -14,   7, -64,   9,  33,  26, -42,  26, -11, -37,  52;
/M: SY='Y';  M=  40,  47,-222,-219,  20,   3, -41, -25, -72, -42,  27,-133,-223, -71,-107,-147, -64,  57, -38,  62;
/M: SY='R';  M=-109, -58, -73,   3, -88,-166, -44,  17,  45, -31, -28,-152,-126,  26,  66,-101, -29,  49,-223, -23;
/M: SY='A';  M=  88,   0,-216,-211,-215, -54,-218,-108, -81, -75, -97,-210, -58,-210, -89, -40,  23,  42,-225, -48;
/M: SY='L';  M= -66, -11, -60, -47, -20,-226,  -7,  42,  -2,  63,   7,  -4,-223, -17, -26, -91,  -2,   7,-222,-203;
/M: SY='Y';  M= -35,  49,-103, -34,  48, -95,  30, -37,   7,-108, -69,-102,-224,   3, -19,  -8, -56, -48,  16, 103;
/M: SY='D';  M=  -7,-223,  97,   6, -53, -26, -45,-226, -38,-226,-221,  18,  24, -52, -48,  18,   0,-169,-236,-216;
/M: SY='Y';  M=-217,  29,-155,-149,  83, -97,   9, -89,-147, -89,-199, -13,-230, -28, -62, -88,-115, -14,   8, 110;
/M: SY='E';  M= -18,   4,  25,  49, -75, -73, -25, -42,  20, -56, -18,  12, -21,  33, -25,   9,  31,   3, -45, -66;
/I:         I=-16; MI=0; MD=-41; IM=0; DM=-41;
/M: SY='P';  M=  55,-131, -37, -43,-231,  29,-218, -88, -23,-172,-124, -25,  56, -56, -21,  22, -24, -98,-231,-225; D=-16;
/I:         I=-16; DM=-41;
/M: SY='Q';  M=  -7,   3,  -2,  19,-119,  -9, -26, -58,   1, -62, -33,  -4,   0,  54,  28,  12,  -4, -28, -50, -33; D=-16;
/I:         I=-16; DM=-41;
/M: SY='D';  M= -28,  -9,  48,  29, -57,   7,   7, -44,  -1, -83, -65,  44,  -9,  21, -24,  12,   0, -50,-232,-133; D=-16;
/I:         I=-16; DM=-41;
/M: SY='P';  M=   1, -19,  35,  49, -79, -13,  -9, -44, -13, -82, -25,  -6,  54,  32, -79,  24,  -7, -67,-228,-216;
/M: SY='D';  M= -41,-131,  73,  27, -61,  34, -42, -98, -35, -93, -88,  34, -73,  -1,  -4,   5,   0, -64,-227,   6;
/M: SY='E';  M= -45, -54,  39,  92,  -7, -19,  -4,-222, -70, -37,-132, -63,-112,  40, -84, -37, -24,-126,-224, -20;
/M: SY='L';  M=-127,-102,-230,-224, -32, -46,-219,  48,-132,  82,  15,-121, -39,-218,-110,-139,-208,  -6,-219,-201;
/M: SY='S';  M= -14, -62, -13,   5,-221, -25, -78, -93, -34, -49,-129,  19,  34,  -1, -12,  72,  45, -68,-229, -76;
/M: SY='F';  M=-111, -66,-233,-227,  94,-231,-217,  35,-224,  50,   7,-225,-229,-225,-223,-221,-138,   7,-203,  -8;
/I:         I=-29; MI=0; MD=-75; IM=0; DM=-75;
/M: SY='K';  M= -33, -20, -50,  17, -42,-116,  16, -70,  62, -32, -37, -19, -38,  46,  42,  18,  -4, -50,-222, -21;
/M: SY='K';  M=  13,-128, -99,  43, -90,-113, -79, -42,  71, -91, -99,-142,  17,  35,  39, -66, -38, -11,-223,-102;
/M: SY='G';  M= -88,-223,  20,-129,-229, 101, -41,-235, -69,-232,-222,  33,-216, -94, -74,-115,-119,-230,-224,-125;
/M: SY='D';  M= -44,-125,  99,  68,-228,-214,-143,-227,-116,-152,-120, -49,-211,  52,-147, -72, -57, -84,-233, -12;
/M: SY='I';  M= -76,-107, -83,  -7, -12,-104, -36,  64,  -9,   4,  -9,-111, -27, -17,  12, -16,  13,  41, -52, -26;
/M: SY='I';  M=-134,  33,-230, -72,  -2,-232,-221,  70,-223,  43,  -9,-225,-226,-221,-224,-218,-206,  54,-217,  24;
/M: SY='T';  M= -30, -49,  -7,  40, -34, -79,  27, -12,  -5, -14, -44, -54,-215,  31,   9, -34,  48,   8, -46,  38;
/M: SY='V';  M= -51, -49,-126,-147,-144, -77,-153,  55, -73,  34, -79, -22,-225, -61,-222,-214, -53,  81,-227,-206;
/M: SY='L';  M= -68, -73, -47, -63, -29,-155, -34,  46, -21,  57, -16, -95,-222,  -5, -51, -11,  10,  23, -53,   5;
/M: SY='E';  M= -37, -72,  46,  59,-120,  10, -37,-114,  18, -88, -98,  17, -53,  21,  11,  32, -53, -63,-227, -37;
/M: SY='K';  M= -36,-109,  18,  33, -36, -43, -54, -27,  58,-115,   1,  26, -21,  26,  28,  -9,   4, -33,-115, -76;
/I:         I=-13; MI=0; MD=-33; IM=0; DM=-33;
/M: SY='N';  M= -25, -24,  28,  22, -91,  -2,  10, -39,  -5, -53, -44,  36, -22,  -6, -33,  16,  18, -10,   1, -37; D=-13;
/I:         I=-13; DM=-33;
/M: SY='D';  M= -57, -60,  63,  41,-110,   7,   2, -84, -66, -41, -73,  35,  -5,  26, -56,  28,  -7, -31, -14, -54;
/M: SY='D';  M= -40, -76,  58,  41, -86,  18, -16, -95,   6,-100, -93,  30,  31,  24, -10,  15, -39, -94,-229, -65;
/M: SY='G';  M= -83,-223,  48,  26,-100,  70,  14,-149, -60, -80, -43,  38, -35, -25, -53,   1, -37,-122,-226, -11;
/I:         I=-45; MD=-115;
/M: SY='W';  M=-104,-104,-101, -65,  19,-222, -91,-152, -62, -68,  -3, -73, -59, -43, -30,-225, -86, -92, 173,  -5; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='W';  M= -65,  27,-235,-224,   9,-110,-102,  -4,-120,   9,  -4,-229, -55,-149,-138, -46, -48, -35, 155,  50;
/M: SY='E';  M= -52,-223, -74,  37, -11,-122, -36,   6,  37,  21, -27, -74,-118,  25,  37,-102,  -4, -17,  34,  34;
/M: SY='G';  M=  36,  41,-218,-220,-217,  80,-222, -52,-217, -48,-207,-207,-219,-216,-222,-119,-123,  51, -80,-218;
/M: SY='R';  M= -94, -20, -27,  43, -33, -76, -13, -43,  28, -38,  12, -99,-215,  24,  62,  15,  10, -11,-221,   1;
/M: SY='N';  M= -76,  24,  13,-207, -42, -67,  10,  -7,   6,  25, -11,  49, -75, -84,  26,  25,   6,  -6,-102,   2;
/M: SY='N';  M= -15, -34,   1,   9,-114,  25,  11,  -7,  -5,   1, -17,  45,   4,  18,   0,   9, -26, -26, -89, -60;
/I:         I=-18; MI=0; MD=-45; IM=0; DM=-45;
/M: SY='T';  M= -41,-239,  -7, -28,-159, -20,-103,-125, -13, -72, -72,  27,   2, -39, -51,   5,  46,-112, -68, -95; D=-18;
/I:         I=-18; DM=-45;
/M: SY='G';  M= -35, -19,  -1, -19, -82,  84, -74,-120,  -7, -60,-122,  18, -42, -18,   2,  -4, -46, -88,-224, -91;
/M: SY='K';  M= -15, -20, -33,  34, -99, -60, -10, -32,  61, -38, -60,  -1, -95,  51,  49, -36, -29, -32, -78,-108;
/M: SY='E';  M= -30, -75, -67,  47, -12,-147, -87,  11,  10, -50, -37, -48, -64,  19,  45, -24,  41,  18, -75,  -3;
/M: SY='G';  M= -48,-223,-212,-222, -76, 108, -80,-148, -81, -54, -97,-198,-115,-128,-223,-124,-214,-227,-220,-109;
/M: SY='W';  M= -39,-169, -72,-221,  33,-225, -47,  26, -59,  45,   5, -48, -98, -67, -70, -73, -81, -18, 110,  67;
/M: SY='F';  M=   6, -60,-230,-225,  86,-138,-222,  42,-222, -41,-120,-222,-226,-225,-223, -81, -93,  67,-209, -35;
/M: SY='P';  M=-125,-237,-213,-203,-229,-216,  14,-219, -91, -68,-215, -61, 131, -95, -74, -82,-206, -72,-226, -74;
/M: SY='S';  M=  47,  13, -88, -25, -43,  -9, -29, -40,  -9, -21, -40, -40, -45, -36,  11,  61,  -4, -22,-225, -58;
/M: SY='N';  M=  -5,-100,  31, -13, -41, -68, -46, -89,   5,-134, -67,  84, -17, -12, -74,  43,  13, -13,-231, -46;
/M: SY='Y';  M= -44,  56,-143, -92,  46,-128,  22, -33, -39, -27, -33,  -5,-227, -69, -53, -21,-133, -17,-193, 110;
/M: SY='V';  M= -65, -56,-228,-223,   9,-133, -36,  21,-102,  46, -57,-223,-226,-220, -32,-215, -21,  81,-224,-138;
/M: SY='E';  M=   2,  -8,   2,  61,-117, -43,   5, -26,  19, -29, -17, -58,-213,  40,  12, -33,  11,   1,-116, -31;
/M: SY='P';  M= -57, -68, -16,  53,  -7, -76,  -6,  24,  10,  11, -45, -58,  53, -28, -11, -55, -49,  15,-223, -84;
/M: SY='I';  M= -15,  10, -37, -33, -63,-122, -37,  41,   2,  24,   0, -22,  27,  15, -18, -30, -13,  23, -18,   3;
/M: SY='P';  M= -14, -76,  25,  14, -78, -16,  16, -43,   0, -28, -45,  12,  49, -13,   0,  16, -12, -32, -58, -34;
/M: SY='P';  M=   7,  -9,   6,  18,-100, -18, -14, -36,  -4, -47, -55, -11,  41,  -9,  -2,   9,  18, -34,-232, -29;
/I:         E1=0; IE=-380; DE=-380;

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Post-processing [info]

COMPETES_HIT_WITH

PS51781

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.

Total number of hits	1'294 in 1'009 different sequences
Number of true positive hits	1'294 in 1'009 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	1
Number of 'partial' sequences	1

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	99.92 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info]	6
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	SH3
Version [info]	6

Cross-references [info]

UniProtKB/Swiss-Prot True positive sequences	1009 sequences ABI1_HUMAN (Q8IZP0), ABI1_MOUSE (Q8CBW3), ABI1_RAT(Q9QZM5), » more Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
UniProtKB/Swiss-Prot False negative sequences	1 sequence ACK_DROME (Q9VZI2)
UniProtKB/Swiss-Prot 'Partial' sequences	1 sequence SRBS1_RAT (P84109)
PDB [Detailed view]	791 PDB 1A0N; 1ABO; 1ABQ; 1AD5; 1AEY; 1AOJ; 1ARK; 1AVZ; 1AWJ; 1AWO; 1AWW; 1AWX; » more